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Cognizin® (cytidine 5′-diphosphocholine), is an endogenous nucleotide naturally found in the body where it is an essential intermediate in the synthesis of the major phospholipid of the cell membranes, phosphatidylcholine. This constitutes a pool for the synthesis of acetyl choline, one of the brain’s main neurotransmitters. There is also evidence of antioxidant activity and a stimulatory effect on the release of dopamine neurotransmitters in the brain; a series of actions which have earned citicoline a role in the enhancement of memory. The KSM-66®Ashwagandha and affron® work here too, via stress reduction and generally improved well-being. Wellmune® has been shown in multiple studies to improve Profile of Mood States score.