See what the experts say on LYMA Laser technology and LLLT in this peer-reviewed evidence.
The science and further reading
There are thousands of scientific journals published on the subject of Low-Level Laser therapy (LLLT) and its regenerative and healing properties. See what your peers are saying on LYMA Laser technology and LLLT in just some of the peer-reviewed evidence for near-infrared laser in plastic surgery.
Glass G.E. Photobiomodulation: A review of the molecular evidence for low level light therapy. Journal of Plastic, Reconstructive & Aesthetic Surgery 2021.
https://pubmed.ncbi.nlm.nih.gov/33436333/
Hode et al. The importance of coherence in phototherapy. Mechanisms for Low-Light Therapy IV 2009.
Karu T. Primary and secondary mechanisms of action of visible to near-IR radiation on cells. Journal of Photochemistry and Photobiology 1998
https://pubmed.ncbi.nlm.nih.gov/10365442/
Glass G.E. Photobiomodulation: The Clinical Applications of Low-Level Light Therapy. Oxford University Press.
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Mechanistic summaries
Avci, P., Gupta, A., Sadasivam, M., Vecchio, D., Pam, Z., Pam, N. and Hamblin, M.R., 2013, March. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. In Seminars in cutaneous medicine and surgery (Vol. 32, No. 1, p. 41). NIH Public Access.
da Silva, J.P., da Silva, M.A., Almeida, A.P.F., Junior, I.L. and Matos, A.P., 2010. Laser therapy in the tissue repair process: a literature review. Photomedicine and laser surgery, 28(1), pp.17-21. https://www.liebertpub.com/doi/full/10.1089/pho.2008.2372
Chung, H., Dai, T., Sharma, S.K., Huang, Y.Y., Carroll, J.D. and Hamblin, M.R., 2012. The nuts and bolts of low-level laser (light) therapy. Annals of biomedical engineering, 40, pp.516-533.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288797/
Avci, P., Gupta, G.K., Clark, J., Wikonkal, N. and Hamblin, M.R., 2014. Low‐level laser (light) therapy (LLLT) for treatment of hair loss. Lasers in surgery and medicine, 46(2), pp.144-151.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944668/
Houreld, N.N., 2019. The use of lasers and light sources in skin rejuvenation. Clinics in dermatology, 37(4), pp.358-364.
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Pre-clinical studies
Gupta, A., Dai, T. and Hamblin, M.R., 2014. Effect of red and near-infrared wavelengths on low-level laser (light) therapy-induced healing of partial-thickness dermal abrasion in mice. Lasers in medical science, 29, pp.257-265.
Ma, H., Yang, J.P., Tan, R.K., Lee, H.W. and Han, S.K., 2018. Effect of low-level laser therapy on proliferation and collagen synthesis of human fibroblasts in vitro. Journal of wound management and research, 14(1), pp.1-6.
https://scite.ai/reports/effect-of-low-level-laser-therapy-YaDaJz
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Clinical trials
Hopkins, J.T., McLoda, T.A., Seegmiller, J.G. and Baxter, G.D., 2004. Low-level laser therapy facilitates superficial wound healing in humans: a triple-blind, sham-controlled study. Journal of athletic training, 39(3), p.223.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC522143/
Kajagar, B.M., Godhi, A.S., Pandit, A. and Khatri, S., 2012. Efficacy of low level laser therapy on wound healing in patients with chronic diabetic foot ulcers—a randomised control trial. Indian Journal of Surgery, 74, pp.359-363.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477409/
Gupta, A.K., Filonenko, N., Salansky, N. and Sauder, D.N., 1998. The use of low energy photon therapy (LEPT) in venous leg ulcers: a double‐blind, placebo‐controlled study. Dermatologic surgery, 24(12), pp.1383-1386.
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General reading
Avci et al. Primary and secondary mechanisms of action of visible to near-IR radiation on cells . Semin Cutan Med Surg 2013.
https://pubmed.ncbi.nlm.nih.gov/10365442/
Karu. Low-Level Laser (light) Therapy (LLLT) in skin: stimulating, healing, restoring. Journal of Photochemistry and Photobiology 1998.
Photobiomodulation: A systematic review of the oncologic safety of Low-Level Light Therapy (LLLT) for aesthetic skin rejuvenation. Aesthetic Surgery Journal Open Forum.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309024/
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